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Chris RockOsmosis Jones (voice)
Laurence FishburneThrax (voice)
David Hyde PierceDrix (voice)
Brandy NorwoodLeah (voice)
Bill MurrayFrank Detorre
Molly ShannonMrs. Boyd
William ShatnerMayor Phlegmming (voice)
Ron HowardTom Colonic (voice)
Sherry Lynn(voice)
Mickie McGowanAdditional Character Voice (voice)
Chris ElliottBob
Elena FranklinShane Detorre
Kid RockKidney Rock
Uncle KrackerKidney Rock (voice)
Carlos AlazraquiAdditional Character Voices (voice)
Rodger BumpassAdditional Character Voices (voice)
Richard Steven HorvitzAdditional Character Voices (voice)
Danny MannAdditional Character Voices (voice)Mickie McGowanAdditional Character Voices (voice)
Jonathan AdamsAdditional Character Voices (voice)
