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Gary CooperWild Bill Hickok
Jean ArthurCalamity Jane
James EllisonWilliam "Buffalo Bill" Cody
Charles BickfordJohn Lattimer
Helen BurgessLouisa Cody
Porter HallJack McCall
Paul HarveyYellow Hand
Victor VarconiPainted Horse
John MiljanGeneral George A. Custer
Frank McGlynn Sr.Abraham Lincoln
Granville BatesVan Ellyn
Anthony QuinnCheyenne Indian
George 'Gabby' HayesBreezy
Mark StrongWells Fargo Agent (uncredited)
Frank AlbertsonA Young Trooper
Purnell PrattCapt. Wood
Fred KohlerJake - A TeamsterPat MoriaritySgt. McGinnis
Charles JudelsTony - The Barber
Harry WoodsQuartermaster Sergeant
Francis McDonaldA River Gambler
George ErnestA Boy
George MacQuarrieGen. Merritt
Fuzzy KnightDave
Everett Brown
Curtis NeroRoustabout
