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Ryan ReynoldsWade Wilson / Deadpool / Juggernaut (voice)
Josh BrolinCable
Morena BaccarinVanessa
Julian DennisonFirefist
Zazie BeetzDomino
T.J. MillerWeasel
Leslie UggamsBlind Al
Karan SoniDopinder
Brianna HildebrandNegasonic Teenage Warhead
Jack KesyBlack Tom
Eddie MarsanHeadmaster
Shioli KutsunaYukio
Stefan KapičićColossus (voice)
Randal ReederBuck
Nikolai WitschlHead Orderly Frye
Thayr HarrisSergei Valishnikov
Rob DelaneyPeter
Lewis TanShatterstar
Bill SkarsgårdZeitgeist
Terry CrewsBedlam
Brad PittVanisher
Paul WuHong Kong Boss
Robert MailletSluggo
Alan TudykLuke - Redneck #1
Matt DamonRedneck #2
Michasha ArmstrongSwat Captain (School)
Joe DoserroBus Driver
Hayley SalesCable's Wife
Islie HirvonenCable's Daughter
Jagua ArnejaTree Trimmer #1
Gerry SouthTree Trimmer #2
Mike DopudPrison Guard
Luke RoesslerCereal Kid
Andy CaneteNeighbor #1
Tanis DolmanNeighbor #2
Eleanor WalkerNeighbor #3
Hunter DillonBranding Boy
Sala BakerOlder Firefist
Sonia SungerNews Reporter (Irene)
Paul WernickNews Cameraman
Rhett ReeseNews Helicopter Pilot
Abiola UthmanChinook Pilot
Tony BaileyBlack Tom Gang MemberDavid CookPriest
Alex KlinerPark Bench CoupleElaine KlinerPark Bench Couple
David LeitchGround Chuck Mutant
Valencia BudijantoZoo Kid
Stefania IndelicatoBystanderMyfanwy WilliamsStrip Club DancerSam ArmstrongStrip Club DancerAlison PickfordStrip Club Dancer
Paul LazenbyStrip Club Baddie
Noah BeggsStrip Club Baddie
Andrei KovskiStrip Club Baddie
Alicia MortonVocalist on 'Tomorrow' (voice)
Fred SavageFred Savage (uncredited)
Andre TricoteuxOn-Set Colossus (uncredited)
James McAvoyCharles Xavier / Professor X (uncredited)
Nicholas HoultHank McCoy / Beast (uncredited)
Evan PetersPeter Maximoff / Quicksilver (uncredited)
Tye SheridanScott Summers / Cyclops (uncredited)
Alexandra ShippOroro Monroe / Storm (uncredited)
Kodi Smit-McPheeKurt Wagner / Nightcrawler (uncredited)
