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Julia RobertsMary Reilly
John MalkovichDr. Henry Jekyll / Edward Hyde
George ColeMr. Poole
Michael GambonMary’s Father
Glenn CloseMrs. Farraday
Kathy StaffMrs. Kent
Michael SheenBradshaw
Bronagh GallagherAnnie
Linda BassettMary's Mother
Ciarán HindsSir Danvers Carew
Henry GoodmanHaffinger
Wendy NottinghamScreaming Girl's Mother
Moya BradyYoung Woman
Emma Griffiths MalinYoung WhoreSasha HanauYoung Mary
Isabella MarshallScreaming Girl
Richard LeafScreaming Girl's Father
Stephen BoxerInspector
Tim BarlowVicarHarry FielderMan with Beard (uncredited)
