Story :Jimmy is a young man who was born without an immune system and has lived his life within a plastic bubble in his bedroom... who pines for the sweet caresses of girl-next-door Chloe. But when Chloe decides to marry her high school boyfriend, Jimmy – bubble suit and all – treks cross-country to stop her.
Cast
Jake GyllenhaalJimmy Livingston
Swoosie KurtzMrs. Livingston
Marley SheltonChloe
Danny TrejoSlim
John Carroll LynchMr. Livingston
Verne TroyerDr. Phreak
Dave SheridanMark
Brian GeorgePushpop
Patrick CranshawPappy / Pippy
Stephen SpinellaChicken Man
Ever CarradineLisa, Mark's Sister
Geoffrey ArendFlipper Boy
BeetlejuiceLi'l Zip
Matthew McGroryHuman Sasquatch
Bonnie MorganRubber Woman
Jason SklarShlomo
Randy SklarDawn
Ping WuEmcee
Zach GalifianakisBus Stop Man
Boti BlissCashier
Pablo SchreiberTodd
Brian GattasTodd
Cinco PaulTodd
Ken DaurioTodd
Malik ToureTodd
Leo FitzpatrickTodd
J.P. CoeTodd
R.J. DurellTodd
Brian FriedmanTodd
Arden MyrinLorraine
Merle KennedyLorraine
Shulie CowenLorraine
Alicia GilleyLorraine
Mandy MooreLorraine
Mitch HollemanJimmy, 4 Years Old
Alex BlackJimmy, 8 Years Old
Tony BlackJimmy, 10 Years Old
Robert Bailey Jr.Neighborhood Boy
Oliver KindredNeighborhood Boy
Brandon de PaulNeighborhood Boy
Steve Van WormerMark's Friend
E.J. CallahanPerris Townie
Charlie DellPerris Townie
Michael LopretePerris Townie
Charles NolandPerris Townie
Emily StewartPerris Townie
Pattie TiercePerris Townie
Gary BullockPerris Sheriff
Susan HawkPerris Waitress
Steven Anthony LawrenceIce Cream Boy
Raja FenskeIndian Boy
Cleo KingMinister
Robert LaSardoSkinny Biker
Jorge CottiniBig Biker
Mindie McCullumRed Hot
Stacy KeiblerWorking Girl
FabioGil
Cyia BattenDancer (uncredited)
Bianca ButtholeMember of 'Betty Blowtorch' (uncredited)
Charles M. KerperCult Member (uncredited)
Katie LohmannCult Member (uncredited)
Daniel MandehrCasino Guy (uncredited)
Michael A. TessieroFan in Leather Pants (uncredited)