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Grey DeLisleSally Avril / Voice of OsCorp (voice)
Phil LaMarrFancy Dan / Homunculus #1 (voice)
Cree SummerGlory Grant / Cobweb / Homunculus #2 (voice)
Tricia HelferFelicia Hardy / Black Cat (voice)
Clancy BrownGeorge Stacy (voice)
Joshua LeBarFlash Thompson (voice)
Vanessa MarshallMary Jane Watson / Hermia (voice)
Daran NorrisJ. Jonah Jameson (voice)
Alan RachinsNorman Osborn (voice)
Alanna UbachLiz Allan / Helena (voice)
Lacey ChabertGwen Stacy (voice)
Miguel FerrerSilvermane (voice)
