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Mark RuffaloDominick Birdsey / Thomas Birdsey
Melissa LeoConcettina Ipolita Tempesta 'Ma' Birdsey
Rosie O'DonnellLisa Sheffer
Archie PanjabiDr. Patel
Kathryn HahnDessa Constantine
John ProcaccinoRay Birdsey
Rob HuebelLeo
Michael GreyeyesRalph Drinkwater
Gabe FazioShawn Tudesco / Dominick and Thomas Acting Double
